ベンチトップバイオリアクターのガス制御

ブロンコスト（Bronkhorst）はバイオリアクターメーカー向けにガス流量制御ソリューションを提供しており、特にベンチトップバイオリアクターで使用できるガス流量コントローラをラインナップしております。このフレキシブルな機器は広いダイナミックレンジを備えており、バイオリアクターメーカーは1台の機器で流量範囲を簡単に変更したり、他のガス種に切り替えたりすることができます。こうすることで、モデルが削減でき、現地在庫の確保、流量制御機器の納期に縛られることが無くなる、といったメリットを得られます。

ほとんどのバイオリアクターでは、発酵食品や飲料向けの使用、ワクチンや医薬品の開発への使用、といった使途に関わらず、目的の生物学的合成を行うために細菌、酵母、または細胞を増殖させるためのガスを供給する必要があります。これらのガスは通常、流量コントローラーを使用して数日から数週間にわたって連続的に追加されます。

ブロンコストのソリューションを見る

Requirements for benchtop bioreactors

For a reliable biological growth process, accurate, repeatable, and stable gas flows are essential. Especially in the R&D environment, a wide range of gas flow rates is necessary to investigate the best growth conditions. For benchtop bioreactors compact gas flow instruments are desired. For manufacturers that build bioreactors on specification for customers, it is desirable to reduce the number of variations of flow instruments, to counteract obstacles in delivery time. Moreover, pressure data is desired to inform the bioreactor user about the current process conditions.

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Important topics

Large dynamic flow range
Easy switching of gas type
High accuracy, repeatability and long-term stability
Pressure information
Compact

Process solution

Large dynamic range

Bioreactor manufacturers would like to build reactors that are as generic as possible, to provide a system for a variety of users. Ideally, one bioreactor setup handles a wide range of gas flow rates. For this application, the FLEXI-FLOW mass flow controller is equipped with an unique flow sensor that measures and controls flow over a wide dynamic range (a high turndown ratio of 1:1000) in combination with excellent accuracy and compatibility with different gas types.

Flow scheme

Easy switching of gas type

As air, oxygen, nitrogen and carbon dioxide are the most common gases in this field, the FLEXI-FLOW has the data of these gases standard on board, so there is no need for additional calibration. Using the on-board Fluidat firmware, you can easily calculate the physical properties of gases, allowing you to reduce the number of instruments needed.

Where a typical range up to 20 l_n/min with four gases has been traditionally covered by 36 models, this can be reduced to 12 models, and with four gases on board even to 3 mass flow controller models. The bioreactor manufacturer and the end-user can decide which of these gases to use by setting a parameter in the software.

FLEXI-FLOW flow controller enabling model reduction

Reduction of gas flow controllers possible

Long-term stability

Due to a capillary chip sensor technology combined with friction-free valve technology and electronics, the FLEXI-FLOW instrument has an excellent accuracy, repeatability and long-term stability. The capillary chip sensor that measures the gas flow remains very stable over the years and does not need calibration. Since the small sensor is less prone to temperature gradients, the short-term stability is very good as well.

Pressure information

Pressure information is desired to inform or alarm the bioreactor user. This accounts for gas supply pressure at the inlet and bioreactor process pressure at the outlet. Limitation of the process pressure is necessary for bioreactors to avoid breakage of the reactor. The FLEXI-FLOW gas flow controller contains pressure measurement and control at the inlet and outlet of the instrument, and as such, this smart instrument is suitable for predictive maintenance of the bioreactor system.

Compactness

The small size of the FLEXI-FLOW instrument will make it a device of choice for compact benchtop bioreactors.

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フレキシブルなガス流量コントローラによる

ベンチトップバイオリアクターのガス流量制御